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Gvither Forte Kit

Greenlife Pharmaceuticals Ltd
2, Bank Lane, Off Town Planning Way, Ilupeju, Lagos State, Nigeria
Email: info@greenlifepharmaceuticals.com, greenlife2001@yahoo.com
Tel: 01-737-8991; 01-871-3181; 0803-343-1338; 0803-569-9324

Brand Name

Gvither Forte Kit

Manufacturer

Therapeutic Class

Antimalarial drugs

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Injection (NRN: 04-3135): Artemether 80 mg per mL; sterile and colourless solution in clear glass ampoule.

Pack size: Gvither Forte kit: Composite kit pack contains 1 sterile Artemether Injection ampoule with sterilised disposable 2 mL syringe and sterile needle.

1 Gvither Forte Kit Box: contains 6 Composite Kit Packs.

Also available: Gvither Injection in 40 mg/mL. Ampoule containing Artemether 40 mg/mL with sterile 2 mL syringe and sterilised needle.

Pharmacology

Artemether and its derivatives act essentially as blood schizonticides. The presence of the endoperoxide bridge appears to be essential for antimalarial activity, generation of singlet oxygen and formation of free radicals. Inhibition of protein synthesis as the basic mechanism of action is suggested in studies which showed morphological changes in ribosomes as well as in the endoplasmic reticulum.

Pharmacokinetics:

Artemether when injected through IM route is rapidly absorbed reaching Cmax within 2-3 hours. It is metabolized in the liver to the demethylated derivatives dihydroartemisinin.

The elimination is rapid, with a T½ of 4 hours. Dihydroartemisinin has T½ of more than 10 hours.

Indications

Treatment of malaria caused by all forms of Plasmodium including severe malaria caused by multiple drug resistant strains of P. falciparum.

Contra-indications

Pregnancy, unless the doctor considers it essential as in the case of cerebral malaria.

Precautions/Warnings

In cerebral malaria and complicated malaria, general supporting therapy may be required.

Interactions

Adverse Effects

The therapeutic dose (700 mg) has virtually no side effects. There are reports of laboratory abnormalities i.e. a decrease in reticulocyte count, an increase in transaminase and ECG changes (Sinus bradycardia). However, these are transient. At high doses, transient abdominal pain, diarrhoea and tinnitus can occur.

Dosage & Administration

 Age  Dose    
Day 1 Day 2 Day 3 Day 4 Day 5
Adult 160 mg (2 amps) 80 mg (1 amp) 80 mg (1 amp) 80 mg (1 amp) 80 mg (1 amp)
Children 4 mg/kg b.wt. 2 mg/kg b.wt. 2 mg/kg b.wt. 2 mg/kg b.wt. 2 mg/kg b.wt.

Storage/Handling Recommendations

Gvither Forte injection should be protected from light and stored at room temperature.

If stored for long periods in the cold, precipitation may occur which may clear on storage at room temperature. If not, the contents of the ampoule should be discarded.

Do not store below room temperature.

Review Date

2015-04-05 04:34:33