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Dosage Form, Composition & NAFDAC Registration Number (NRN)
Tablets (NRN: 04-6474): Diclofenac Sodium USP 50 mg, 100 mg; enteric coated tablets.
The active agent Diclofenac belongs to the non-steroid anti-inflammatory group and exhibits marked anti-rheumatic, anti-inflammatory and analgesic properties. Diclofenac inhibits prostaglandin synthetase and has an inhibitory action on platelet aggregation.
Lofnac is thus suitable for the treatment of rheumatic states and non-rheumatic pain, inflammatory pain. Lofnac tablets have protective coating to gastric juices. They are suitable for patients whose clinical condition indicates a daily dose of 100 mg.
After oral administration, Diclofenac is rapidly and completely absorbed. The plasma concentrations are linearly dose dependent.
Rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder, postoperative pain, musculoskeletal injuries, dysmenorrhoea, sprain, dislocation, tenosynovitis, tendinitis.
Patients with peptic ulcers, unexplained gastrointestinal disorders, liver or kidney damage, high blood pressure, and elderly patients require attentive medical supervision.
Simultaneous use of Lofnac with Lithium products or Digoxin products increases the Lithium or Digoxin levels in the blood.
The simultaneous administration of Acetylsalicylic acid leads to decrease in the blood concentration of the active agent Diclofenac.
Dosage & Administration
The initial daily dose is usually 150 mg; the daily dose is divided into 2-3 individual administrations.
Children over one year old receive 1-3 mg/kg/day.
Lofnac tablet is taken unchewed with a glass of water. Take with food to minimize GI upset.