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Lofnac Injection

Greenlife Pharmaceuticals Ltd
2, Bank Lane, Off Town Planning Way, Ilupeju, Lagos State, Nigeria
Email: info@greenlifepharmaceuticals.com, greenlife2001@yahoo.com
Tel: 01-737-8991; 01-871-3181; 0803-343-1338; 0803-569-9324

Brand Name

Lofnac Injection

Manufacturer

Greenlife Pharma Ltd, Lagos, Nigeria.

Therapeutic Class

Non-steroidal anti-inflammatory drugs (NSAIDs), Systemic

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Injection (NRN: 04-): Each mL contains: Diclofenac Sodium BP 25 mg, Benzyl Alcohol BP 40 mg (as preservative), Water for Injection BP q.s.

Pack size: Ampoule of 3 mL; Box of 10 ampoules of 3 mL.

Pharmacology

Diclofenac is a nonsteroidal compound with a pronounced anti-inflammatory, analgesic and antipyretic properties. Diclofenac acts by inhibiting the prostaglandin biosynthesis, which plays major role in the causation of inflammation, pain and fever.

Pharmacokinetics:

Approximately 20 minutes after IM injection of 75 mg of Diclofenac, a mean peak plasma conc. of 2.5 mcg/mL is attained. Diclofenac becomes bound to serum proteins at rate of 99.7% chiefly to albumin. The biotransformation of Diclofenac involves partly glucoronidation and hydroxylation followed by glucoronidation.

Indications

Acute severe pain due to inflammatory and degenerative forms of rheumatism, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, renal colic, painful post-traumatic and post operative inflammation and swelling. Pain following dental surgery. Acute attacks of gout.

Contra-indications

Peptic ulcer, hypersensitivity to the active substance or excipients.

Precautions/Warnings

Strict accuracy of diagnosis and dose. Medical surveillance are imperative in the patients with symptoms indicative of gastrointestinal ulceration with ulcerative colitis, or with Crohn's disease, patients suffering with hepatic impairment and pregnancy.

Interactions

Adverse Effects

Dosage & Administration

Storage/Handling Recommendations

Store in a cool and dark place, protect from light.

Review Date

2015-04-05 04:43:37