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Interflox

Seadar Pharmaceuticals Ltd
Plot 303A, Abisogun Leigh Street, Adeniji Estate, Ogba GRA, Ogba, Ikeja, Lagos
Email: seadarpharma@gmail.com
Tel: 234802-313-0510

Brand Name

Interflox

Manufacturer

PT Interbat, JI. H.R.M. Mangundiprojo no. 1 Buduran, Sidoarjo-61252, East java, Indonesia

Therapeutic Class

Antibacterial, Quinolones

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Tablet (NRN: 04-2391): Each film-coated tablet contains: Ciprofloxacin HCI.1 H2O equiv. to Ciprofloxacin 250 mg.

Pack size: Box contains 3 strips of 4 film coated tablets.

 

Caplet (NRN: 04-2559): Each film-coated caplet contains: Ciprofloxacin HCI.1 H2O equiv. to Ciprofloxacin 500 mg.

Pack size: Box contains 3 strips of 4 film coated tablets.

INTERFLOX

Pharmacology

Interflox contains Ciprofloxacin, a synthetic broad-spectrum antimicrobial agent that is included in fluoroquinolone class of antibiotics. It has in vitro activity against a wide range of gram-negative and gram-positive organisms.

The bactericidal action of Interflox results from inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV (both type II topoisomerase), which are required for bacterial DNA replication, transcription, repair, and recombination.

Indications

Uncomplicated urinary tract infections (acute cystitis);

Complicated urinary tract infections;

Acute uncomplicated pyelonephritis;

Bones, joints, skin and soft tissue infections as well as GI tract infections;

Urethral and endocervical gonorrhoea;

Respiratory tract infection, except pneumonia caused by Streptococcus pneumoniae;

Complicated intra-abdominal infection (used in conjunction with Metronidazole).

Ciprofloxacin was the most active compound against Pseudomonas aeruqinosa, Serratia marcescens and Enterobacter cloacae compared to levofloxacin, lomefloxacin, pefloxacin and trovafloxacin in respiratory tract infections treatment.

Contra-indications

Hypersensitivity to Ciprofloxacin or other quinolone derivates.

Precautions/Warnings

Caution for any intake by patients with impaired renal function.

Patients with known cerebral seizures should only be treated with ciprofloxacin if suitable anti-convulsant therapy is ensured. To avoid the incidence of crystalluria, Interflox tablet should be swallowed with plenty of water.

Interactions

Adverse Effects

Interflox is well tolerated by most patients. The side effects usually mild and rare include :

Skin reations.

Gastrointestinal complaints: nausea (3%), vomiting (1%), diarrhea (2%), dyspepsia (1%), abdominal pain.

Disturbances of the central nervous system: dizziness (1%), headache (1%), tiredness, infrequent visual disturbances.

Dosage & Administration

Unless otherwise prescribed, the following doses are recommended:

Mild/moderate infections of the urinary tract: 2 x 250 mg daily.`

Severe infections of the urinary tract: 2 x 500 mg daily

Mild/moderate infections of the respiratory tract, bones, joints, skin and soft tissue: 2 x 500 mg daily

Severe infections of the respiratory tract, bones, joints, skin and soft tissue: 2 x 750 mg daily

Infection of the gastrointestinal tract: 2 x 500 mg daily

Acute gonorrhoea: single dose of 250 mg.

To achieve adequate concentration in acute osteomyelitis, the dosage should not be less than: 2 x 750 mg daily

Dosage for patients with impaired renal function: if creatinine clearance is less than 20 mL/minute, the normal dose must be administered only once daily or reduced by half if taken twice daily.

Interflox should be swallowed with water. They may be taken independentely of meals, taking it on an empty stomach will accelerate absorption. For acute infections, the treatment normally takes 5 to 10 days.

Generally, the treatment should be continued consistently for at least 3 days after disappearance of clinical symptoms.

Storage/Handling Recommendations

keep out of the reach of children. store in a cool dry place.

Review Date

2016-12-19 04:10:19