Plot 1 Junaid Dosunmu Street,Central Business District, Alausa, P.0. Box 3560 Ikeja, Lagos, Nigeria.
Tel: + 234-1-774-1205
Nigerian German ChemicalS Plc,
Dosage Form, Composition & NAFDAC Registration Number (NRN)
Tablet (NRN: 04-7272): Griseofulvin BP 500 mg.
Pack size: 10 x 10’s; 2 x 10’s (in blisters).
Suspension (NRN: 04-4702): Griseofulvin 125 mg per 5 mL.
Griseofulvin is indicated for the treatment of ringworm infection of namely: Tinea capitis (ringworm of scalp); Tinea barbac (fungus infection of beard caused by T. faviforme, T. metagraphytes and M. canis); Tinea pedis and Tinea manas (ring worm of the feet and hands); Tinea cruris and Tinea corporis (ringworm of the groin and the body); Onychomycosis (fungus infection of the nails).
The drug is contraindicated in patients with porphyria, hepatocellular failure, and individuals with the history of hypersensitivity to griseofulvin.
Griseofulvin may diminish the effects of coumarin anticoagulants and oral contraceptives possibly by increasing their rate of metabolism. It may enhance the effects of alcohol.
Effects of griseofulvin is diminished by concurrent therapy with barbiturates.
Use of griseofulvin in pregnancy is not recommended.
Skin rashes, dryness of mouth, an altered sensation of taste and gastro intestinal disturbances. Angiodema, erythema multiforme, exfoliative dermatitis, proteinuria, leucopenia and other blood dyscrasis, candidiasis, paraesthesia, photosensitisation and severe headache, depressions, confusion, dizziness, insomnia and fatigue are the most common side effects.
Dosage & Administration
500 mg daily in 2 or 4 divided doses. In certain infections like Tinea capitis, a larger dose of 1.5 g daily may be necessary.
10 mg per kg daily, administered as a single dose or in divided doses.
Griseofulvin tablets should be kept in a tightly closed container.
Oral suspension should be stored below 25oC and in its original container.