268, Ikorodu Road, Obanikoro P.O. Box 7210, Shomolu, Lagos. Km 38, Lagos-Abeokuta Exp, Sango Otta.
Alpha Laboratories Ltd, 33/2 A.B. Road, Pigdamber-453 446, India.
Dosage Form, Composition & NAFDAC Registration Number (NRN)
Tablet (NRN: 04-2195): Aminophylline BP 100 mg.
Pack size: 500's in amber coloured bottle.
Injection (NRN: 04-6756): Each 10 ml contains: Aminophylline BP 250 mg, Water for injection BP q.s.
Pack size: Ampoule of 10 mL.
Description: Aminophylline is a stable mixture of theophylline and ethylenediamine.
Reversible airways obstruction.
Severe acute asthma. Aminophylline is indicated for relief of acute bronchial asthma and reversible bronchospasm associated with chronic bronchitis and emphysema, and in status asthmaticus; congestive heart failure, Cheyne-Stokes respiration, reduction of coughing, expectoration and exertional dyspnoea in emphysema patients, and for cardiac paroxysmal dyspnoea.
Aminophyllin injections are primarily for use in emergency situations.
Aminophylline should not be given to patients with active peptic ulcers, since it may increase the volume and acidity of gastric secretions.
Patients with a history of hypersensitivity to aminophylline or theophylline should not be treated with Aminophylline.
Do not administer Aminophylline with other xanthine preparations.
Safe use of Aminophylline in pregnancy has not been established.
The following solutions should not be mixed with aminophylline in i.v. fluid. Chlorpromazine, dobutamine, epinephrine, norepinephrine, bitartrate, insulin, oxytetracycline, penicillin G, potassium, phenobarbitol, phenytoin, prochlorperazine, promazine, vancomycin, verapamil, vitamin C, vitamin B complex with C.
The most consistent adverse reactions observed with therapeutic amounts of aminophylline are:
Gastrointestinal: nausea, vomiting, anorexia, bitter aftertaste, dyspepsia, heavy feeling in the stomach, and gastrointestinal distress.
Central nervous system: dizziness, vertigo, light-headedness, headache, nervousness, insomnia, and agitation.
Cardiovascular: palpitation, tachycardia, flushing, extrasystoles and cardiac rhythm disturbances.
Respiratory: increase in respiratory rate.
Dosage & Administration
Oral: 100 - 300 mg three to four times after food.
I.V.: Slow IV injection over 20 mins., 250 - 500 mg (5 mg/kg).
Oral: 5 mg/kg daily after food.
I.V.: Slow IV injection over 20 mins., (5 mg/kg).
Store in a cool, dry and dark place.