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I-GESIC Eye Drop

Al-Tinez Visions Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Email: altinezvisions@gmail.com
Tel: 01-7418609, 08296588658, 0708900917

Brand Name

I-GESIC Eye Drop

Manufacturer

Centaur Pharmaceuticals Pvt. Ltd. Plant-1, Plot No. 3, Tivim Industrial Estate, Karaswada, Mapusa, Goa-403526, India.

Therapeutic Class

Nonsteroidal anti-inflammatory drugs (NSAIDs), Eye

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Eye drops (A4-5244): Diclofenac sodium 0.1% (w/v); Sorbic acid 0.2% (w/v)

Pack size: Plastic dropper bottle of 5 mL.

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Pharmacology

Diclofenac sodium is one of a series of phenylacetic acids that has demonstrated anti-inflammatory and analgesic properties in pharmacological studies.

It inhibits the enzyme cyclooxygenase, which is essential in the biosynthesis of prostaglandins (PGs). PGs have been shown in many animal models to be mediators of certain kinds of intraocular inflammation.

In studies performed in animal eyes, PGs have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis and increased intra-ocular pressure.

Limited, if any, systemic absorption occurs with I-GESIC.

Indications

I-GESIC is indicated for:

• The treatment of post-operative inflammation in patients who have undergone cataract extraction and IOL implantation.

• Trabeculoplasty and photorefractive keratectomy.

• In ocular inflammatory conditions like iritis, iridocyclitis, chronic conjunctivitis and post-operatively.

• For the temporary relief of pain and photophobia in patients undergoing corneal refractive surgery.

Contra-indications

Hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and while using soft hydrogel contact lenses.

Precautions/Warnings

I-GESIC, like other NSAIDs, should be used with caution in surgical patients with known bleeding tendencies or who are receiving other medications, which may prolong bleeding time.

Elevations in intra-ocular pressure may occur with I-GESIC following its use in cataract surgery.

Safety and effectiveness of I-GESIC in paediatric patients have not been established.

Pregnancy and Lactation:

Since there is no adequate data available to confirm the safely of I-GESIC during pregnancy and lactation, it is not advisable to use it unless there is a compelling reason to do so.

Interactions

There are no major drug interactions with the use of 1-GESIC.

It can be concurrently used with cycloplegics, mydriatics, beta-blockers, antibacterials and carbonic anhydrase inhibitors.

I-GESIC should be used with caution along with oral anticoagulants.

Adverse Effects

Use of I-GESIC may be associated with transient burning and stinging sensation, keratitis and elevated intra-ocular pressure.

Rarely patients on I-GESIC may experience abdominal pain, chills, fever and headache.

Dosage & Administration

One drop of I-GESIC should be instilled in the affected eye qid beginning 24 hours after surgery and continuing throughout the first two weeks of the post-operative period.

In inflammatory conditions, instill 1 drop qid till resolution of symptoms takes place.

Storage/Handling Recommendations

Store at temperature between 15-30°C in a dark place.

Do not freeze.

Keep medicines out of the reach of children.

Review Date

2016-05-10 12:23:07