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AminoGard

Phillips Pharmaceuticals Limited
Plot 122-132, Apapa-Oshodi Expressway, Afprint Ind. Est., Iyano-Osolo B/stop, Lagos Nigeria.
Email: mktng.phillips@gmail.com, info@phillipsnigeria.com
Tel: 0805-6292409; 0803-6761764
Website: http://phillipspharma.com

Brand Name

AminoGard

Manufacturer

Stedman Pharmaceuticals Pvt. Ltd, C-4, SIDCO Pharmaceuticals Complex, Alathur, Thiruporur, 603 110, Tamilnadu, India.

Therapeutic Class

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Syrup(NRN: A4-6545): Amino acids, Vitamins

Pack size: bottle of 200 mL with measuring cup.

Aminogard Liquid

Powder (NRN: A4-6249): Amino acids, Vitamins

Pack size: sachet of 10 x 5 g.

Aminogard Granules

Pharmacology

AminoGard granules provide biologically utilizable source material for protein synthesis when used with concentrated calorie sources (such as hypertonic dextrose or fat emulsion), electrolytes, vitamins, and minerals. Administered orally after appropriate dilution or with minimal calorie supplementation, it enhances the conservation of body protein.

Over the long haul, AminoGard granules will help keep the muscles primed for top performance and the body conditioned for greater fitness and overall health. A constantly adequate supply of the amino acids will enable the body needs and will help to achieve a better-fat-to-muscle ratio. Increased quantities of essential micronutrients (Thiamine, Riboflavin, Pyridoxine, Folic Acid, Cyanocobalamin, etc.) are required for the success of any anticatabolic or anabolic strategy as micronutrient depletion occurs after trauma or in convalescing condition.

Pharmacokinetics:

Amino Acids: Unlike fats and carbohydrates, Amino acids require the removal of Amine group. Removal of amine group occurs through a 2 step process: transamination reaction and oxidative deamination. All excess Amino acids are deaminated. This results in the production of Ammonia which is toxic and is eliminated via urea cycle. Urea cycle occurs in liver resulting in the formation of urea, which is eliminated by excretion as urine.

Liver is the major site of Nitrogen metabolism in the body. The carbon skeletons are generally conserved as carbohydrate via gluconeogenesis, or as fatty acid via fatty acid synthesis pathways.

In this respect Amino acids fall into three categories: Glucogenic, Ketogenic or Glucogenic and Ketogenic. Glucogenic amino acids are those that give rise to a net production of Pyruvate or TCA cycle intermediates, such as a-Ketoglutarate or Oxaloacetate, all of which are precursors to glucose via gluconeogenesis.

All Amino acids except Lysine and Leucine are at least partly Glucogenic. Lysine and leucine are the only Amino acids that are solely Ketogenic, giving rise only to AcetylCoA or AcetoacetylCoA, neither of which can bring about net Glucose production.

A small group of Amino Acids comprised of Isoleucine, Phenylalanine, Threonine, Tryptophan and Tyrosine give rise to both Glucose and fatty acid precursors and are thus characterized as being Glucogenic and Ketogenic. Finally, it should be recognized that Amino acids have a third possible fate. During times of starvation the reduced carbon skeleton is used for energy production, with the result that it is oxidized to CO2 and H2O.

Vitamin B2 (Thiamine): Thiamine is absorbed from the gastrointestinal net and is widely distributed to most body tissues.

Indications

Aminogard granules are indicated as nutritive supplement in pregnant women, malnourished children, the elderly and convalescing patients.

Contra-indications

Hypersensitivity to any component of this formulation, in conditions of irreversible liver insufficiency and severe uremia when dialysis possibilities are lacking.

Branched chain amino-acids in AminoGard liquid is contra-indicated in those with the rare inborn errors of metabolism like Maple Syrup Urine Disease.

Precautions/Warnings

AminoGard liquid should be used cautiously in severe hepatic diseases and acute renal impairment. Appropriate laboratory tests, especially those for the monitoring of liver functions and renal functions, should be performed periodically during the course of use of the product. AminoGard liquid should be given with caution to very sick children due to the risk of inducing hyperphenylalaninemia.

Phenylketonurics: Contains Phenylalanine.

Usage in Pregnancy:

Amino acid supplementation in pregnancy can cause meaningful reduction in the incident of IUGR (intrauterine growth restriction) in mothers having risk factors for delivering growth retarded fetus and thereby improve perinatal outcome. However, safety and efficacy of this formulation in pregnant women have not been established.

Usage in Lactation:

Safety and efficacy of this formulation in lactating mothers have not been established.

Interactions

Adverse Effects

 AminoGard liquid is generally well tolerated. Nausea and rarely hypersensitivity reactions may occur.

Dosage & Administration

Adults:

One tablespoonful (15 mL) to be taken twice daily.

Children:

One teaspoonful (5 mL) to be taken 2-3 times daily.

Not recommended for children below 1 year.

The required dosage should be administered using the given measuring cup with markings.

Storage/Handling Recommendations

Store protected from sunlight.

Keep out of the reach of children.

Review Date

2016-08-02 11:02:50