72 Agege Motor Road, Alakara, Mushin.
Tel: 01-81507361, 2663986, 234-8033018912, 08033054541
Dexcel Ltd, A Dexon Company, Or-Akiva, P.O.B. 50, Hadera 38100, Israel.
Dosage Form, Composition & NAFDAC Registration Number (NRN)
Tablet (NRN: 04-7389): Glibenclamide 5 mg.
Pack size: 10 x 10's
Glibenclamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs.
Oral hypoglycaemic agent of choice in the management of non-insulin dependent diabetes mellitus (NIDDM).
Hypersensitivity to one of its ingredients; Pregnancy.
Gluben is not intended for treatment of insulin-dependent diabetes (diabetes mellitus), severe or unstable diabetes, ketosis or acidosis as a diabetes complication, diabetic coma.
Do not use in serious medical conditions such as major surgery, infective disease, severe burn or injury.
Do not use this drug without consulting your physician if you are breastfeeding, if you suffer, or have suffered in the past from dysfunction of the cardiovascular system, the liver, the kidney/urinary tract, the gastrointestinal tract (e.g. severe diarrhea, continuous vomiting, severe problems with intestines, slow stomach emptying), the thyroid, severe infection, female hormone changes (e.g. during puberty, pregnancy) mental stress, underactive pituitary gland, underactive or overactive adrenal gland, malnutrition, high fever or any other serious diseases.
Do not drink wine, and/or alcoholic beverages during treatment with this drug. This drug may cause photosensitivity upon exposure to the sun, therefore avoid exposure to the sun and protect yourself with long clothing, hat, sunscreen creams, etc. If you smoke, inform your physician before starting treatment with this drug. It is recommended to perform controlled exercise during treatment with this drug. The use of Gluben is in addition to the diet that was prescribed to you and not instead. It is recommended to perform blood and urine sugar tests and liver and kidney function tests during treatment.
Notify your doctor if you are using salicylates, anticoagulants (e.g. dicumarol), antidepressants from the MAOl group or lithium, antihypertensives such as beta-blockers and calcium channel blockers, cough and cold preparations, appetite suppressants, antifungals, oral contraceptives, diuretics, non-steroidal anti-inflammatory drugs, probenecid (anti gout), corticosteroids including octreotide, tetracyclines, chloramphenicol, quinolones such as ciprofloxacin (antibiotics), quinidine (for the heart), cimetidine, rantidine (for gastric ulcer), theophylline (for asthma), anti-bacterial sulfonamides, asparaginase (for leukemia), clofibrate and benzafibrate (for reduction of cholesterol), nicotinic acid, thyroid hormones, pentamidine (for pneumonia) or phenylbutazone.
In addition to the desired effect of the drug, some side effects may appear such as constipation, diarrhea, nausea, vomiting, drowsiness, headache, changes in taste, dizziness, heartburn, stomach ache, increased sensitivity to the sun, changes in appetite. The medicine may cause change in the colour of urine or stools, in this case, there is no cause for concern.
Side effects requiring special attention: Skin irritation or pruritus, fever, sore throat, excessive thirst, loss of appetite, increased urination (rare).
Dosage & Administration
Adult and children over 12 years: ½ - 1 tablet daily at breakfast.
Do not exceed the recommended dosage.
The drug is usually not intended for children and infants. This medicine is to be taken at regular intervals, as determined by the physician. If you have forgotten to take a dose, take it as soon as you remember, but never take two doses together.
Directions for use:
Do not chew and do not crush. Can be halved. This drug should be taken with water.
Chills, cold sweat, cold pale skin, headache, excessive hunger, unusual weight gain, anxiety, nervousness, confusion, drowsiness, slurred speech, shakiness, convulsion, fast heartbeat, fainting or unconsciousness: discontinue treatment and contact your physician immediately.
Store in a cool place.