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Nifedin Retard

Pemason Pharmaceuticals Limited
72 Agege Motor Road, Alakara, Mushin.
Email: pemas80@yahoo.com
Tel: 01-81507361, 2663986, 234-8033018912, 08033054541

Brand Name

Nifedin Retard

Manufacturer

Dexcel Ltd, A Dexon Company, Or-Akiva, P.O.B. 50, Hadera 38100, Israel.

Therapeutic Class

Calcium channel blockers (CCBs)

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Tablet (NRN: 04-4499): Nifedipine 20 mg.

How to Identify the Product: Sustained release, pink, round, film coated tablets.

Pack size: 30 tablets in foil blister strips (3 blisters of 10 tablets).

Nifedin Retard

Pharmacology

Nifedipine is one of a group of medicines called calcium channel blockers. It lowers blood pressure and has anti-anginal properties. Nifedipine relaxes the muscle lining of small vessels throughout the body and in this way brings high blood pressure down to normal. Nifedipine also reduces the pain (angina pectoris) which occurs when the heart is starved of oxygen, by improving oxygen supply to the heart muscle.

Indications

Nifedin Dexcel Retard tablets are used to treat all grades of high blood pressure (hypertension) and to prevent the condition called angina pectoris.

Contra-indications

Have you taken products containing nifedipine before and reacted badly to them, e.g. developed wheezing or rash? Are you sensitive to calcium antagonists (e.g. verapamil, diltiazem, amlodipine, felodipine)? Do you suffer from the heart conditions known as aortic stenosis (a narrowing of the aorta, which is the largest blood vessel leading from the heart, resulting in reduced blood flow through the aorta or unstable angina (unpredictable chest pains of varying levels of severity)? Have you had a myocardial infarction (heart attack) during the past twelve hours or within the past month? Do you suffer from acute attacks of angina? Do you suffer from malignant hypertension (rapid rise in blood pressure requiring medical treatment?

If the answer to any of these questions is yes, you should not take Nifedin Dexcel Retard tablets.

If you have ever had a myocardial infarction, Nifedin Dexcel 10 Retard and Nifedin Dexcel 20 Retard should not be used to prevent a second myocardial infarction.

Are you pregnant or trying to become pregnant? Nifedipine should not be taken by pregnant women nor by women who could become pregnant, because there is a risk of damage to the unborn baby. Are you breastfeeding? Nifedipine should not be taken by breast-feeding women as it passes into the breast milk.

Precautions/Warnings

Do you suffer from poor cardiac reserve ( a reduced output from the heart)? Do you suffer from severe low blood pressure (hypotension). Are you a diabetic? Nifedipine may cause temporary high blood sugar level. Do you suffer from a liver disease?

If the answer to any of these questions is yes, Nifedin Dexcel Retard tablets should be used with caution and therefore tell your doctor before you use these tablets.

Treatment with this medicine should be discontinued should cardiac ischaemic pain (chest pain) be experienced within 1-4 hours of the introduction of therapy and you should consult your doctor.

If you are on kidney dialysis and you have very high blood pressure and a low blood volume, you may experience a sudden drop in blood pressure so consult your doctor before taking this medicine.

Interactions

Are you receiving any other medical treatment, particularly any of the following drugs: cimetidine, digoxin, quinidine, rifampicin, beta blocking drugs, diltiazem or other drugs to lower blood pressure? Do not take Nifedin Dexcel Retard tablets until you have discussed all these other medicines with your doctor.

Adverse Effects

A number of side effects are known for Nifedipine: Headache, flushing, fast heartbeat (tachycardia) and palpitations may occur, particularly on commencement of treatment with Nifedipine. Swelling of ankles of ankles or legs has been observed. A sensation of numbness, prickling or tingling, or heightened sensitivity may occur occasionally; a sensation of dizziness and tiredness may also develop.

Skin reactions may occur such as rash, itching and urticaria (itching wheals). Other skin reactions such as sensitivity to light, peeling or reddening of the skin may occur in isolated cases; usually, they regress after discontinuation of the drug. Systemic allergic reactions (these may appear as yellowing of the skin (jaundice), or they may cause symptoms such as a rash or fever) which also usually regress after discontinuation of the drug may occur in isolated cases. Gastrointestinal disorders such as nausea and altered bowel habit may occur occasionally. Other less frequently reported side effects include muscle pain, trembling and visual disturbance. You may feel the need to pass urine more often. Rarely, mood changes may occur.

If you experience any other side effects, and especially the following, discuss them immediately with your doctor: chest pain, thickening of gums, yellowish discoloration of the skin and perhaps, the whites of the eyes (this is called jaundice). These side effects should disappear when treatment with Nifedipine is stopped. Occasionally, the treatment of high blood pressure may lead to breast enlargement, particularly in older men.

If you are diabetic, you must talk to your doctor before taking Nifedin Dexcelm Retard tablets. If you experience any unusual symptoms when taking these tablets consult your doctor.

Dosage & Administration

It is important that you take your medicine at the right time. Treatment may be continued indefinitely.

The usual dose for adults is one Nifedin Dexcel 20 Retard tablet (20 mg) twice a day.

Your doctor may advise a different dose within the range 10 mg twice daily to 40 mg twice daily; e.g. if you suffer from liver problems, therapy should be started with Nifedin Dexcel 10 Retard (10 mg) twice daily, or if your condition requires a higher dosage, therapy could be increased to two Nifedin Dexcel 20 Retard (40 mg) twice a day (only if your doctor has advised it). Usually Nifedin Dexcel 10 Retard is recommended as initial dosage.

Ideally take your doses at twelve hour intervals. Nifedin Dexcel Retard tablets should be swallowed whole with water and should not be broken or chewed. Nifedin Dexcel Retard tablets are not recommended for treatment of children.

If you forget to take a dose, take it as soon as you remember and continue, as prescribed on the next day allowing at least twelve hours before taking the following dose.

Overdosage:

In case of an accidental overdose, contact your nearest hospital.

Storage/Handling Recommendations

Nifedipine is sensitive to light. The tablet should be protected from light and stored in the manufacturer's original container. Do not remove the tablets from the blister or carton except when ready to take them.

You should store the tablets in a cool and dry place, out of the reach of children.

Review Date

2015-07-08 08:14:37