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Pemacain

Pemason Pharmaceuticals Limited
72 Agege Motor Road, Alakara, Mushin.
Email: pemas80@yahoo.com
Tel: 01-81507361, 2663986, 234-8033018912, 08033054541

Brand Name

Pemacain

Manufacturer

Shijiazhuang No. 2 Pharmaceutical Factory, 188, Gongnong Road, Shijiazhuang Hebei, China.

Therapeutic Class

Antibacterial, Penicillins

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Injection (NRN: 04-4204):Procaine penicillin 300,000 i.u., Pencillin potassium (or sodium) 100,000 i.u.

How to identify the Product: Sterile dry powder for reconstitution.

Pack size: In vials of 400,000 i.u.

Pemacain

Pharmacology

This preparation is available in the form of a sterile dry powder containing Benzylpenicillin potassium (or sodium) and Procaine penicillin with suitable amount of suspending and buffering agents. The advantage of such a preparation is that it can exert both the prompt action due to the high initial blood levels produced by the soluble potassium salt, and the prolonged action of the insoluble procaine penicillin salt which is absorbed and excreted slowly. Therefore, a single dose injection of this preparation can maintain an effective concentration in blood for 12-24 hours.

Indications

As its peak blood concentration is relatively low, it is only indicated in mild infections caused by penicillin-sensitive bacteria such as tonsillitis, scarlet fever, crysipelas, furuncles and carbuncles. It is also effective for syphilis, Vincent's angina and gonorrhea.

Contra-indications

Hypersensitivity to any of the penicillins or other ingredients in the formulation.

Precautions/Warnings

Before administration, skin tests of procaine and penicillin should be made. It should not be administered to patients hypersensitive to penicillin and procaine.

The suspension prepared by adding a suitable amount of water for injection into the vial should be stored below 10oC and used up within 24 hours.

Interactions

The major interaction is with Methotrexate. Consult your healthcare professional if you are on other medications.

Adverse Effects

At high doses procaine penicillin can cause seizures and CNS abnormalities due to procaine present in it.

Dosage & Administration

It is given by IM injection only. A suitable amount of water for injection is added into the vial before use. 400,000-800,000 IU each time, once or twice a day.

Storage/Handling Recommendations

Keep in well closed container and store in a dry place.

Review Date

2015-07-08 08:18:46