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Erythronez-250/500

Al-Tinez Pharmaceuticals Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Tel: 01-4826452; 0802-307-7320, 0803-305-7978

Brand Name

Erythronez-250/500

Manufacturer

Alpa Laboratories Ltd, 33/2, A.B. Road, Pigdamber - 453 446, India.

Therapeutic Class

Antibacterial, Macrolides

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Tablet(NRN: A4-0917): Each film coated tablet contains:Erythromycin Stearate BP equivalent to Erythromycin 250 mg. Excipients q s.

Pack size: 10 tablets in a strip.

 

Tablet(NRN: A4-0916): Each film coated tablet contains: Erythromycin Stearate BP equivalent to Erythromycin 500 mg. Excipients q s

Pack size: 10 tablets in a strip.

erythronez erythronez 300

Pharmacology

Erythromycin acts by binding to the 50S ribosomal subunit of bacteria and inhibits protein synthesis.

MECHANISM OF ACTION:

They act by binding to 50 S ribosomal subunit of bacteria and inhibits protein synthesis.

PHARMACOKINETICS:

As it is inactivated in stomach. Oral formulations are enteric coated. It diffuses rapidly into all tissues except brain and rapidly crosses the placental barrier. It is metabolised in liver and excreted largely via bile and faeces.

ONSET OF ACTION:
2 – 4 hours

DURATION OF ACTION:
6 – 12 hours.

It exhibits activity against Clostridia, C. diptheriae, Listeria, Campylobacter, Strep. Pyogenes, Strep. Viridans, H. influenzae, B. pertussis, N. meningitidis, Mycoplasma and Legionella.

Indications

Upper respiratory tract infections, acute pneumonia, wound and burn infections , acne vulgaris.

As an alternative antibiotic to Penicillin in allergic patients. In severe impetigo unresponsive to topical antibiotics and in folliculitis.

Contra-indications

Hypersensitivity to any of the macrolide antibiotic or any of the formulating components.

Precautions/Warnings

Hepatitis with cholestatic jaundice, resembling viral hepatitis or extra hepatic biliary obstruction and reversible abnormalities in LFTs may be associated with prolonged or repeated therapy. Interacts with Theophylline, Digoxin, Carbamazepine, oral anticoagulants.

Paediatrics: Reduced dose necessary.

Pregnancy: Safe

Lactation: Contraindicated

Elderly: No special problem.

Interactions

Anticoagulants: Efficacy enhanced, leading to haemorrhages

Bromocriptine: Efficacy potentiated, leading to toxicity.

Carbamazepine: Dangerous toxic side effects requiring resuscitative measures and hospitalisation

Digoxin: Serum levels of digoxin enhanced leading to toxicity

Disopyramide: Increased disopyramide plasma levels leading to arrhythmias

Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.

Methylprednisolone: Decreases methylprednisolone clearance.

Penicillins: Alters efficacy, may be synergistic or antagonist.

Theophylline: Increased serum theophylline levels resulting in toxicity. Decreased serum levels of erythromycin

Triazolam: Increased CNS depression.

Adverse Effects

Nausea, epigastric pain and diarrhoea, skin rash and cholestatic jaundice. Hypersensitivity reactions, oral candidiasis, thrombophlebitis, fever.

Dosage & Administration

Adults:

250-500 mg 3-4 times daily.

Gonorrhoea: 500 mg 6 hourly for 6-7 days.

Syphillis: 1 gm 6 hourly for 10-15 days (30days in late Syphillis).

Prophylaxis against Streptococci: 250 mg 12 hourly.

Children:

7.5-25 mg/kg body wt. 6 hourly or 15-50 mg/kg body wt 12 hourly.The dose can be doubled if required in severe cases.

Storage/Handling Recommendations

Store in a cool dry place. Keep out of the reach of children.

Review Date

2017-10-25 03:54:32