Al-Tinez Pharmaceuticals Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Tel: 01-4826452; 0802-307-7320, 0803-305-7978

Brand Name



Alpa Laboratories Ltd, 33/2, A.B. Road, Pigdamber - 453 446, India.

Therapeutic Class

Antimalarial drugs

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Tablet (NRN: A44734): Quinine Sulpahe BP 300 mg.

Pack size: 10 strips of 10 tablets in a carton.



Quinine inhibits nucleic acid synthesis, protein synthesis, and glycolysis in Plasmodium falciparum and can bind with hemozoin in parasitized erythrocytes. However, the precise mechanism of the antimalarial activity of quinine sulfate is not completely understood.

Activity In Vitro and In Vivo

Quinine sulfate acts primarily on the blood schizont form of P. falciparum. It is not gametocidal and has little effect on the sporozoite or pre-erythrocytic forms.


  • Resistant strains of falciparum malaria,
  • Symptomatic relief of muscle cramps, including nocturnal cramps.
  • Treatment of uncomplicated Plasmodium falciparum malaria.


Pregnanacy, lactation, tinnitus, optic neuritis, myasthenia gravis.

Quinine Sulphate is also contraindicated in patients with the following:

  • Prolonged QT interval. One case of a fatal ventricular arrhythmia was reported in an elderly patient with a prolonged QT interval at baseline, who received quinine sulfate intravenously for P. falciparum malaria
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • Hemolysis can occur in patients with G6PD deficiency receiving quinine.
  • Known hypersensitivity reactions to quinine.
  • Known hypersensitivity to mefloquine or quinidine: cross-sensitivity to quinine has been documented.

These include, but are not limited to, the following:

  • Thrombocytopenia
  • Idiopathic thrombocytopenia purpura (ITP) and Thrombotic thrombocytopenic purpura (TTP)
  • Hemolytic uremic syndrome (HUS)
  • Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia)
  • Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness.
  • Optic neuritis. Quinine may exacerbate active optic neuritis.


Atrial fibrillation, cinchonism, Haemoglobinuria, Renal or hepatic impairment.

Paediatrics: Dose should be reduced

Pregnancy:May cause defects in the developing foetus

Lactation: Drug passes in to breast milk.


With Anti-coagulants, Pyrimethamine, Digoxin & muscle relaxants such as Orphenadrine.

Adverse Effects

Cinochonism, acute haemolytic anaemia, tinnitus, headache, blurred vision, vomitting, diarrhoea, abdominal pain, vertigo.

Dosage & Administration

Adult: 300-600 mg 3 times daily for 5-7 days.

Children: 25 mg/kg/day 8 hourly for 7 days.

Storage/Handling Recommendations

Store in a cool, dry and dark place. Keep out of the reach of children.

Review Date

2017-10-25 03:59:41