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Peflac Tablet

Al-Tinez Pharmaceuticals Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Tel: 01-4826452; 0802-307-7320, 0803-305-7978

Brand Name

Peflac Tablet

Manufacturer

Baroque Pharmaceuticals Pvt. Ltd, Sokhada-388 620, Ta. Khambhat, Gujarat, India. Mfg. Lic. No G/1217

Therapeutic Class

Antibacterial, Quinolones

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Tablet (NRN: A4-5428): Pefloxacin 400 mg.

Pack size: 2 x 7's.

Pharmacology

Pefloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division.

Mechanism of action:

The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Indications

Fluoroquinolones are used to treat bacterial infections in many different parts of the body. They are both bactericidal and bacteriostatic, are effective against both gram positive and gram negative organisms including: Pseudomonas, gonoccoci, H. influenzae, Staphylococci, Streptococci, etc. It is not active against anaerobes. It is not effective for rhinitis, lnfluenza or other viral infections.

They are mainly used for gastrointestinal infections.

Contra-indications

Contraindicated in children below 12 years and in patients with a history of convulsion. Also contra-indicated in pregnancy and lactation.

Hypersensitivity reactions.

Precautions/Warnings

Patients with brain or spinal cord disease including arterisclerosis in the brain or epilepsy or other seizures.

Fluoroquinolones may cause neurological symptoms, renal impairment and hepatic disease.

Patients with renal disease (alone) or renal disease and hepatic disease (together) may have an increased chance of side effects.

Interactions

Antacids, Iron supplements or Sucralfate: May interfere with the efficacy of Pefloxacin.

Didanosine: Didanosine may reduce the effectiveness of Pefloxacin.

Adverse Effects

Generally well tolerated. However, gastrointestinal disturbances, muscle and/or joint pains, photosensitivity reactions, neurological disturbances (headache, insomnia), and thrombocytopenia have been reported by patients in rare cases.

Dosage & Administration

By mouth: The usual dose for adults is one tablet (400 mg) twice a day taken along with food. Initially, two tablets (800 mg) can be administered to get fast higher valid concentration in blood.

Storage/Handling Recommendations

Store in a cool dry place out of the reach of children.

Review Date

2017-10-25 04:08:10