products-page-bottom-left-box

Delvac Injection

Al-Tinez Pharmaceuticals Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Tel: 01-4826452; 0802-307-7320, 0803-305-7978

Brand Name

Delvac Injection

Manufacturer

Alpa Laboratories Ltd, 33/2, A.B. Road, Pigdamber - 453 446, India.

Therapeutic Class

Non-steroidal anti-inflammatory drugs (NSAIDs), Systemic

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Injection (NRN: A4 - 1473): Diclofenac Sodium BP 75 mg, Benzyl alcohol BP 4% v/v.

Pharmacology

Diclofenac sodium acts primarily by inhibition of the prostaglandin synthesis.

More than 99% of Diclofenac is reversibiy bound to plasma albumin. Diclofenac sodium penetrates into the synovial fluid and is also detected in the milk. The mean terminal half life in plasma is about 2 hours.

Diclofenac Sodium is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulphate conjugates of the metabolites. Approximately 65% of the dose is excreted in the urine and 35 % in the bile.

Indications

Diclofenac sodium is indicated in the relief of pain & inflammation in conditions such as rheumatic disease:

  • Osteo-arthritis,
  • Rheumatoid arthritis,
  • Primary dysmenorrhoea,
  • Acute gout,
  • Post operative pain,
  • Inflammation,
  • Low back pain,
  • Ankylosing spondylitis,
  • Acute musculo-skeletal disorders,
  • Periarthritis (Frozen shoulder),
  • Tendinitis, Tenosynovitis,
  • Bursitis,
  • Sprains and dislocations,
  • Pain following dental surgery,
  • Painful inflammatory conditions in gynaecology.

Contra-indications

Hypersensitivity reactions, active or recurrent peptic ulcers, asthmatic patients in whom attacks of asthma are precipitated by aspirin or other NSAIDS, pregnancy, lactation.

Precautions/Warnings

Allergic reactions: As with other NSAIDS, allergic reactions including anaphylaxis have been reported with Diclofenac sodium. However, these conditions are very rarely observed.

Fluid retention & Edema: Renal toxicity associated with NSAIDS are seen in patients with conditions leading to a reduction in renal blood flow.

Hepatic effects: During Diclofenac sodium treatment, the level of serum transarninases may increase / remain transient with continued therapy, to minimize the severity of the hepatic injury, symptoms of hepatotoxicity.

Gastrointestinal effects: Patients having a history of GI ulceration, haematemesis or melaena, ulcerative colitis, Crohn's disease, cardiac and renal insufficiency, elderly patients.

Use in pregnancy:

It is possible that Diclofenac sodium may cause uterine contraction.

Not to be used in Neonates.

Interactions

Diclofenac sodium, like other NSAIDS, through effects on renal prostaglandins may cause increased toxicity of certain drugs like digoxin, methotrexate and cyclosporine.

Dlclofenac sodium increases lithium plasma levels and decreases lithium renal clearance.

Diclofenac Sodium and other NSAIDs can inhibit activity of diuretics.

Diclofenac in vitro interferes minimally or not at all with the protein binding of Salicylic acid, Tolbutamide, Prednisolone or Warfarin.

Adverse Effects

The most common adverse reactions are gastrointestinal upset and fluid retention.

Others are Epigastric pain, nausea, diarrhoea, tiredness, insomnia, skin rash, itching, retention of fluid.

Dosage & Administration

Adults:

100-150 mg daily in 2-3 divided doses.

Maintenance therapy: 50-100 mg in divided doses.

Storage/Handling Recommendations

Store in a cool place. Protect from light.

Keep all medicines out of reach of children.

Review Date

2016-02-12 05:37:38