Doxac Capsule

Al-Tinez Pharmaceuticals Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Tel: 01-4826452; 0802-307-7320, 0803-305-7978

Brand Name

Doxac Capsule


Medipharco 8 Nguyen Truong To St., Hue City, Vietnam.

Therapeutic Class

Antibacterial, Tetracyclines

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Capsule (NRN: A4-4406): Doxycycline 100 mg.

Pack size: box of 10 blisters x 10 capsules.


Tetracycline antibiotics are protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex.


In treatment of a variety of infectious diseases:

  • Diseases caused by Brucella, Pasteurella, Rickettsia.
  • Pulmonary infection, urogenital infection and ophthalmic infections caused by Chlamydiae.
  • Pulmonary infection, urogenital infection and ophthalmic infection caused by Mycoplasma.
  • ENT infections and bronchi (pulmonary) infection caused by Haemophilus influenzae.
  • Gonorrhea. Infections caused by Treponema.
  • Cholera caused by Vibrio cholerae.
  • Acnes caused by Propionibacterium acnes.
  • For preventing malaria caused by Plasmodium falciparum.


  • Patients known to be hypersensitive to any of the Tetracyclines.
  • Pregnancy and lactation.
  • Children under 8 years old.
  • Serious liver failure patients.


Avoid the prolonged treatment because of the super-infection.

Stop using the drug when photosensitivity reactions occurs.


Drug Interaction Comments
Antacids (aluminum-, calcium- or magnesium- containing) Decreased absorption of doxycycline Give antacids containing aluminum, calcium, or magnesium 1–2 hours before or after doxycycline
Anticoagulants, oral Decreased plasma prothrombin activity Monitor PT carefully; adjust anticoagulant dosage as needed
Anticonvulsants (carbamazepine, barbiturates, phenytoin) Possible decreased doxycycline half-life  
Bismuth subsalicylate Decreased absorption of doxycycline If concomitant use cannot be avoided, give doxycycline at least 2-3 hours before bismuth subsalicylate
Hormonal contraceptives Decreased effectiveness of oral contraceptive Use of a second form of contraceptive during treatment with doxycycline is advised
Iron-containing preparations Decreased absorption of doxycycline Give doxycycline 2 hours before or 3 hours after iron-containing preparations
Methoxyflurane (no longer commercially available in the US) Fatal renal toxicity  
Penicillins Decreased efficacy of penicillins Avoid concomitant use
Proton-pump inhibitors Decreased absorption of doxycycline  
Retinoids, oral (e.g., acitretin, isotretinoin) Additive adverse CNS effect of pseudotumor cerebri (benign intracranial hypertension) Avoid concomitant use
Urinary catecholamine assay Possible false elevation secondary to interference with fluorescence test  

Adverse Effects

  • Reduction of enamel formation. 
  • Diarrhoea, nausea.
  • Urticaria, photosensitivity reactions.

Inform your doctor of any adverse reaction related to drug use.

Dosage & Administration

Normal indications: take the drug in the meal

Adults over 60 kg body weight: 2 capsules a day

Adults under 60 kg body weight: 2 capsules on the first day, followed by a maintenance dose of 1 capsule

Children over 8 years old: 4 mg/kg body weight per day.

Acute gonorrhea:

  • Male: 3 capsules on the first day, in 2 divided doses, followed by 2 capsules for 2-4 days.
  • Female: 2 capsules a day.

Primary and secondary syphilis: 3 capsules a day, in 3 divided doses for less than 10 days.

Urethra, cervical, rectal inflammations caused by Chlamydia trachomatis: 2 capsules a day for less than 10 days.

Acnes: 1 capsule a day for 10-15 days, then reduce the dose to 1 capsule every 2 days.

For preventing malaria: take 1 capsule 1-2 days before entering the malaria endemic area, then take 1 capsule daily for 4 weeks after leaving the malaria endemic area.

Storage/Handling Recommendations

Store in dry places, below 30ºC, protect from light.

Review Date

2017-10-27 08:34:48