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Voather Suspension

Visko Pharmacy Limited
9/26 Udi Road Asata, Enugu, Enugu State, Nigeria.
Email: nnamdi@viskopharm.org
Tel: 234-80-35085021, 234-70-31601265, 234-80-37430071
Website: http://visko.biz/

Brand Name

Voather Suspension

Manufacturer

Yanzhou Xier Kangtai Pharmaceutical Co.,Ltd.

Private Economy Garden, Xinyan Town, Yanzhou City, Shandong China.

 

Therapeutic Class

Antimalarial drugs

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Suspension (NRN: A4-7514): Artemether 180 mg/60 mL; Lumefantrine 1080 mg/60 mL.

Pack size: 1 X 10

Pharmacology

PHARMCOKINETICS:

Artemether administered orally is absorbed rapidly reaching therapeutic levels within 60 - 90 minutes. Pack plasma concentration is achieved in about 2 hours after dosing. 

Artemether is rapidly and extensively metabolite dihydroartemisin.Artemether and dihdroartemisin are bound to human plasma protein and this binding is linear.

The elimination of Artemether and dihydroartemisin from the plasma is rapid with an elimination half-life of about 2 hours.

Lumefantrine (a highly lipophilic compound) absorption starts after a lag-time of about 2 hours with peak plasma concentration in about 6 - 8 hours administation.

Lumefantrine is administered very slowly with a terminal half-life of 2 to 3 days in healthy individuals and 4 to 6 days in patients with faclparum malaria.

Food enhances the absorption of both Artemether and lumefantrine therefore patients are encouraged to take the medication with fatty foods if possible.

Indications

VOATHER Suspension an Artemisinin-based conbination therapy (ACT) is indicated for the treatment of malaria in children caused by all forms of plasmodium.

Contra-indications

Vother Suspension is formulated specifically peadiattric use therefore there are no strict contra-indications for the use of artemether in children.

Voather suspension is contraindicated in individuals hypersensitive to any of the ingredients. Patients who are taking drugs known to prolong the QT interval such as certain antibiotics (Macrolides,fluoroquinolones,and imidazole) or family history of cardiac arrhythmias are advised to be cautions.

Precautions/Warnings

Vather Suspension is not recommended for prophylaxis. Patients who remain averse to food during treatment should be closely monitored as the risk of recrudescence may be greater.

Interactions

No particular detrimental drug-drug interaction was observed. However slice grapefruit juice inhibits the metabolism of some antimalarias,it is not advisable to drink grape juice while taking Voather.

Adverse Effects

Voather suspension is well tolerated by infants and children. Patients previously treated with antimalarias which can influence the EGG pattern e.g. Halofantrine and quinine,should be given a reasonable period of time before starting treatment with Voather suspension.

Common side effects which may occur include: dizziness, anorexia, nausea, vomiting, diarrhea, coughing and rashes.

Dosage & Administration

Body weight (kg) Daily dose (mL)
   1st Day 2nd Day 3rd Day
0 hr/8 hr 24 hrs/36 hrs 48 hr/60 hrs
5 kg to less than 15 kg 7 mL/7 mL 7 mL/7 mL 7 mL/7 mL

VOATHER Suspension is designed for use in children.

To make up the suspension take the following steps:

- Open the bottle after breaking the seal and add purified water up to the 60 mL mark on the bottle.

- Shake the bottle very well until a uniform suspension is achieved. It may be necessary to make up the volume to 60 mL by adding a little more water. This suspension is stable for 7 days.

- To administer shake the bottle first before administering the dose. A full therapy of 3 days is important in order to aviod recrudescence.

Storage/Handling Recommendations

Voather bottle for suspension should be stored below 30°C away from light and humidity.

Powders from suspension are stable for two years if kept in a closed bottle.

Voather suspension should not be used after the date marked ”EXP“ on the pack.

Keep out of reach and sight of children. 

Review Date

2016-10-28 03:21:16