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Sivolexin

Adpharm Pharmaceuticals Limited
60, Ajao Road, Surulere, Lagos State, Nigeria
Email: adpharm2010@yahoo.com; info@adpharmltd.com
Tel: +234(0)818-839-0519, +234(0)807-408-4334. Mobile: 08033481022
Website: http://adpharmltd.com/

Brand Name

Sivolexin

Manufacturer

YANZHOU XIER KANGTAI PHARM

Therapeutic Class

Antibacterial, Cefalosporins

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Capsule(NRN: A4-5624): Each capsule contains Cefalexin monohydrate equivalent to 250 mg/ 500 mg Cefalexin.

Pack size: 10 x 10's

Sivolexin Capsule

Pharmacology

Broad and medium spectrum antibiotics.

PHARMACOLOGICAL ACTION:

Cefalexin is an acid-stable cephalosporin and is well absorbed from the gastro-intestinal tract. Peak plasma concentrations, reached at about 1 hour after ingestion of the drug, are approximately 9 and 18 ug/mL after oral doses of 250 and 500 mg, respectively.

Cefalexin inhibits bacterial cell-wall synthesis in a manner similar to that of penicillin. In-vitro sensitivity does not necessarily indicate in-vivo efficacy. Cefalexin is active in vitro against both gram-positive and gram-negative micro-organisms. Group A Strep. pyogenes, the viridans group, and non-hemolytic streptococci, Strep. (D.) pneumoniae, penicillin-resistant and penicillin-sensitive Staph. aureus, Staph. epidermis, Cl. perfringens, List. monocytogenes, B. subtilis, C. diphtheriae, N. gonorrhoeae, N. meningitides, and A. israelii are highly sensitive to this agent, many being suppressed by concentrations of 0,004 to 1 ug/mL.

Gram-negative bacteria are generally less susceptible, but the majority strains of Salmonella, including S. typhi, most Shigella, all Pr. mirabilis, and about 75% of E. coli, 60 % of para-colon strains are inhibited by 1 to 6 ug/mL. Indole producing strains of Proteus Enterobacter (Aerobacter), Pseudomonas, and an occasional strain of Klebsiella are highly resistant to cefalexin. Enterococci and H. influenza are also insensitive to the drug.

The ingestion of food may delay absorption.

Indications

Infections caused by susceptible organisms.

Contra-indications

Patients who are known or suspected to be allergic to other cephalosporins should not be treated with cefalexin.

Precautions/Warnings

Side-effects include nausea, vomiting, diarrhoea and abdominal discomfort. Skin rashes occur in about 1% of patients treated with cefalexin and rises in serum transaminases have been noted.

Eosinophilia and neutropenia have occurred in a few patients. Supra-infection with resistant micro-organisms, particularly Candida, may follow treatment. Care is necessary in treating patients known to be hypersensitive to penicillin or with known histories of allergy.

Reduced dosage is necessary in patients with impaired kidney function. The urine of patients taking cefalexin may give a false positive reaction (or glucose with copper-reduction reagents. Positive results to the Coomb's test have been reported with cefalexin.

Interactions

Adverse Effects

Side-effects include nausea, vomiting, diarrhoea and abdominal discomfort. Skin rashes occur in about 1% of patients treated with cefalexin and rises in serum transaminases have been noted. Eosinophilia and neutropenia have occurred in a few patients. Supra-infection with resistant micro-organisms, particularly Candida, may follow treatment.

Care is necessary in treating patients known to be hypersensitive to penicillin or with known histories of allergy. Reduced dosage is necessary in patients with impaired kidney function. The urine of patients taking cefalexin may give a false positive reaction (or glucose with copper-reduction reagents. Positive results to the Coomb's test have been reported with cefalexin. 

Dosage & Administration

The usual adult dose is 250-500 mg every 6 hours and for children 25 to 50 mg per kg body mass daily in divided doses. When high doses are required the use of a parenteral cephalosporin should be considered.

In patients with impaired kidney function smaller doses should be employed: with creatinine clearances of 5, 20 and 50 mL per minute, daily doses should not exceed 0.5, 1.5 and 3 g respectively and 8, 25 and 50 mg per kg respectively in children. 

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:

See under "Side-effects and Special Precautions". Serious acute hypersensitivity reactions may require epinephrine, aminophylline and corticosteroids.

Storage/Handling Recommendations

Store below 25°C. Protect from light.

KEEP OUT OF THE REACH OF CHILDREN.

Review Date

2017-08-12 08:07:27