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Secgyl

Al-Tinez Pharmaceuticals Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Tel: 01-4826452; 0802-307-7320, 0803-305-7978

Brand Name

Secgyl

Manufacturer

ALPA LABORATORIES LTD, 33/2, A.B. Road, Pigdamber-453446

Therapeutic Class

Antibacterial, Nitroimidazole

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Tablet(NRN:A4-5068): Each film coated tablet contains: Secnidazole 500 mg.

Pack size: 4 Tablets in a strip.

secgyl

Pharmacology

Secnidazole is the first nitroimidazole to offer a 3-day antiprotozoal activity from one single dose. With its prolonged half life, secnidazole offers an effective treatment and thus ensures improved patient compliance because of the short duration of treatment with excellent therapeutic efficacy.

Secnidazole exhibits activity against anaerobic protozoa Entamoeba histolytica.

Giardia lamblia and Trichomonas vaginalis. Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm secnidazole.

The plasma elimination half life is about 20 hours. The majority of secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours).

The pharmacokinetic profile of secnidazole gives it the longest half-life of all the second generation nitroimidazoles, ensuring 72-hourtherapeutic blood levels from a 2 gm single dose.

Indications

1. Intestinal Amoebiasis
2. Hepatic Amoebiasis
3. Urethritis and Vaginitis due to Trichomonas vaginalis
4. Giardiasis

Contra-indications

Secnidazole is contraindicated for those patients who are hypersensitive to imidazole derivatives.

Patients should be advised not to take alcohol during treatment with secnidazole (because of possibility of antabuse effect).

Administration of secnidazole should be avoided to patients with a history of blood dyscrasia.

Precautions/Warnings

Patients should be advised not to take alcohol during treatment with secnidazole (because of possibility of antabuse effect). Administration of secnidazole should be avoided to patients with a history of blood dyscrasia.

Interactions

Administration of secnidazole with disulfiram is not recommended:
Confusional state & paranoid reaction may occur. Use of secnidazole simultaneously with warfarin requires close monitoring: increased effect of oral anticoagulants and of the hemorrhagic risk is likely.

USE IN PREGNANCY AND LACTATION:

Secnidazole may be prescribed in pregnancy after the first trimester. As with other similar drugs, secnidazole should not be administered during the first trimester of pregnancy or during lactation because secnidazole is found in placenta and breast milk.

Adverse Effects

The clinical studies have shown that secnidazole is characterized by very good tolerance and no serious adverse reactions have been reported to date.

The following side-effects may be observed with secnidazole as with all nitroimidazole derivatives & are rarely serious.

Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, and stomatitis.

Occasional side effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.

Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, and peripheral neuropathy with secnidazole, gastrointestinal disorders e.g. nausea, vomiting, epigastric pain, etc. have been reported in very rare cases.

Dosage & Administration

Secnidazole tablet should be administered orally.

The dosage schedule of secnidazole tablet is mentioned below:

Adult: 1.5 g daily as single or in divided doses for 5 days.

Child: 30 mg/kg daily for 5 days. Oral Amoebiasis, giardiasis, trichomoniasis.

Storage/Handling Recommendations

Store in a cool, dry place.

Keep medicines out of reach of children.

Review Date

2016-12-02 07:19:56