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BG Cream

BG Pharma & Healthcare Limited
19, Savanah Street, Off Adetola Street, Aguda, Surulere, Lagos, Nigeria
Email: info4bgpharma@rockmail.com, admin@bgpharmaandhealthcare.com, elimino2000@yahoo.com
Tel: 0803-311-5234; 01-844-18946
Website: http://bgpharmaltd.com

Brand Name

BG Cream

Manufacturer

BG Pharma & Healthcare Limited

Therapeutic Class

Anti-infective/Corticosteroid combinations, Skin

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Cream (NRN: A4-3340): Clobetasol Propionate BP 0.05% w/w, Gentamincin Sulphate BP equiv. to Gentamicin 0.1% w/w, Miconazole Nitrate BP 2% w/w, Chlorocresol BP 0.1 w/w, (as preservative)

Pack Size: 15g Tube

BG Cream

Pharmacology

PHARMACODYNAMICS:

Clobetasol propionate is a highly active corticosteroid with topical anti-inflamatory activity. The major effect of clobetasol propionate on skin is a non-specific anti-inflammatory response, partially due to vasoconstriction and decrease in collagen synthesis.

Miconazole nitrate is a potent broad-spectrum antifungal and antibacterial agent with marked activity against dermatophytes, pathogenic yeasts (eg Candida spp) and many Gram-positive bacteria including most strains of Streptococcus and Staphylococcus.

Gentamycin is antibacterial agent.

PHARMACOKINETICS:

Percutaneous penetration of clobetasol propionate varies among individuals and can ba increased by the use of occlusive dressings, or when the skin is inflamed or diseased.

Mean peak plasma clobetasol propionate concentrations of 0.63 ng/mL occurred in one study eight hours after the second application (13 hours after an initial application) of 30g clobetasol propionate 0.05% ointment to normal individuals with healthy skin.

Following the application of a second dose of 30g clobetasol propionate cream 0.05% mean peak plasma concentrations were slightly higher that the ointment and occured 10 hours after application.

In a separate study, mean peak plasma concentrations of approximately 2.3 ng/mL and 4.6 ng/mL occurred respectively in patients with psoriasis and eczema three hour after a single application of 25g clobetasol propionate 0.05% ointment.

Following percutaneous absorption of clobetasol propionate, the drug probably follows the metabolic pathway of systemically administered corticosteriods, i.e metabolism of clobetasol has never been fully characterised or quantified.

Following topical administration of 100 mg miconazole nitrate cream, plasma concentrations of 0.01 µg/mL were never exceeded. Allowing for a 100 fold increase due to the occlusive effects of the ointment base, if the whole of a 30 g tube (containing 600 mg miconazole) was applied at once, maximum plasma levels would be of order of 6 µg/mL.

This would correspond approximately to an iv dose of 5 mg/kg. Similar plasma levels are achieved in rabbits after an oral dose of 40 mg/kg and in rats and rabbits after an itravenousdose of 20 mg/kg (extrapolated value).

Indications

Clobetasol propionate is a very active topical corticosteroid which is of particular value when used in short courses for the treatment of more resistant dermatoses such as psoriasis(excluding widespread plaque psoriasis), recalcitrant eczemas, lichen planus, discoid erythematosus, and other skin conditions which do not respond satisfactorily to less active steriods.

For the topical treatment of inflamed dermatoses where infection by susceptible organisms and inflammation co-exist, eg intertrigo and infected eczema. Moist or dry eczema or dermatitis including atopic eczema.

Primary skin infections: Impetigo contagiosa, superficial

Contra-indications

Precautions/Warnings

Interactions

(clobetasole Propionate with gentamicin & Miconazole cream) 

3-in-1 Action Cream 

  • Anti inflammatory
  • Arti fungal
  • Anti bacterial

Adverse Effects

Dosage & Administration

Storage/Handling Recommendations

Review Date

2017-03-22 06:36:28