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Eyemolol

Al-Tinez Visions Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Email: altinezvisions@gmail.com
Tel: 01-7418609, 08296588658, 0708900917

Brand Name

Eyemolol

Manufacturer

ALPA LABORATORIES LTD. 33/2, A.B. Road,Pigdamber – 453 446 Indore (M.P.)

Therapeutic Class

Antiglaucoma preparations and Miotics

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Drop(NRN:A4-8022): Timolol Maleate BP Eq. To Timolol 0.5% w/v, Benzalkonium Chloride BP 0.01%w/v (as preservative)

Pack size: 10 mL vial.

eyemolol

Pharmacology

Timolol belongs to a group of medicines called beta-blockers. These medicines block beta-receptors in the heart, lungs and other areas of the body.

When given as eye drops, this medication acts on receptors in the blood vessels of the eye and causes them to constrict. This lessens the amount of watery fluid (aqueous humour) that passes out of the vessels into the eye-ball.

Timolol also blocks the area of the eye that actively produces aqueous humour.

Timolol is used to treat glaucoma. This is a condition where the fluid drainage from the eye is impaired, resulting in fluid build-up and increased pressure in the eye.

Indications

TIMOLOL is indicated for the reduction of elevated intraocular pressure. In clinical trials it has been shown to reduce intraocular pressure in: - Patients with ocular hypertension

- Patients with ocular open-angle glaucoma

- Aphakic patients with glaucoma.

- Some patients with secondary glaucoma

- Patients with narrow angles and a history of spontaneous or iatrogenically induced narrow-angle closure in the opposite eye in whom reduction of intraocular pressure is necessary.

TIMOLOL is also indicated as concomitant therapy in patients with pediatric glaucoma who are inadequately controlled with other antiglaucoma therapy.

Contra-indications

TIMOLOL is contraindicated in patients with:

- Bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease.

- Sinus bradycardia; second and third degree atrioventricular block; overt cardiac failure; cardiogenic shock.

- Hypersensitivity to any component of this product.

Precautions/Warnings

As with other topically applied ophthalmic drugs, this drug may be absorbed systematically. The same adverse reactions found with systematic administration of beta-adrenergic blocking agents may occur with topical administration. Patients who are already receiving a beta-adrenergic blocking agent orally and who are given.

TIMOLOL should be observed for a potential additive effect either on the intraocular pressure or on the known systemic effects of beta blockade. In patients with angle-closure glaucoma, the immediate objective of treatment is to reopen the angle. This requires constricting the pupil with a miotic.

TIMOLOL has little or no effect on the pupil.

When TIMOLOL is used to reduce elevated intraocular pressure in angle-closure glaucoma, it should be used with a miotic and not alone.

The preservative in TIMOLOL may be deposited in soft contact lenses; therefore, TIMOLOL should not be used while wearing these lenses.

The lenses should be removed before applications of the drops and not to be reinserted earlier than 15 minutes after use.

WARNING

You should not wear soft contact lenses while you are using this medicine. This it because the medicine contains a preservative that can be absorbed by soft contact lenses and cause eye irritation.

Interactions

There may be some absorption of timolol from the eye into the bloodstream. If timolol eye drops are used when the following medicines are taken, there may be a decrease in the rate and strength of the heart beat quinidine diltiazem verapamil beta-blockers e.g. atenolol.

There may be a drop in blood pressure if timolol eye drops are used when the following medicines are taken: antihypertensives (such as nifedipine) beta-blockers e.g. atenolol.

Adverse Effects

- Headache

- Visual disturbances

- Allergic reaction to active ingredient Low blood pressure (hypotension)

- Inflammation of the eye, causing pain and redness (conjunctivitis) Stinging and redness

- Slow heart rate (bradycardia).

- Breathing difficulties due to a narrowing of the airways (bronchospasm).

- Disorders of the front layer of the eye (cornea).

- Inflammation of the surface of the eye (keratitis).

- Dry eyes.

- Burning, itching and painful sensations in the eye.

NOT TO BE USED IN:

- Asthma.

- Chronic obstructive pulmonary disease.

- Defect of the heart's electrical message pathways resulting in decreased function of the heart (heart block).

- Failure of the heart to maintain adequate circulation (cardiogenic shock).

- History of asthma.

- Known sensitivity or allergy to any ingredient.

- Severe heart failure.

- Slow heart rate of less than 50 beats per minute (bradycardia).

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, slop using this medicine and inform your doctor or pharmacist immediately.

Dosage & Administration

The usual dose is one drop in the affected eye(s) twice a day.

Storage/Handling Recommendations

Store in a cool and dark place.

SHELF LIFE 36 months.

Review Date

2016-05-11 04:57:45