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Eyebetsol-N

Al-Tinez Visions Limited
9, Olowogbowo Str off Obokun Str by Coker Rd, Ilupeju, Lagos
Email: altinezvisions@gmail.com
Tel: 01-7418609, 08296588658, 0708900917

Brand Name

Eyebetsol-N

Manufacturer

ALPA LABORATORIES LTD. 3312, A.B. Road, Pigdamber - 453 446

Therapeutic Class

Anti-infective/Corticosteroid combinations, Eye/Ear

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Drop(NRN: A48135): Betamethasone Sodium Phosphate BP 0.1 % w/v, Neomycin Sulphate BP eq. to Neomycin 0.5% w/v, Thiomersal BP 0.005% w/v (As Preservative).

Pack size: 10 mL vial.

eyebetsol

Pharmacology

Betamethasone Sodium Phosphate is a glucocorticoid receptor agonist. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.

Betamethasone Sodium Phosphate binds to plasma transcortin, and it becomes active when it is not bound to transcortin. Neomycin actively transported across the bacterial cell membrane, binds to a specific receptor protein on the 30 S subunit of bacterial ribosomes, and interferes with an initiation complex between mRNA (messenger RNA) and the 30S subunit, inhibiting protein synthesis. DNA may be misread, thus producing nonfunctional proteins; polyribosomes are split apart and are unable to synthesize protein.

PHARMAKINETICS:

Betamycin-N eye/ear drop contain the water-soluble corticosteroid betamethasone sodium phosphate, and have the advantage of containing no steroid particles to cause irritation.

This is of particular value in ophthalmic work. Neomycin sulphate is an antibiotic, active against many strains of Gram-positive and Gram-negative bacteria including Staph. aureus, E. coli, Klebsiella spp., H. influenzae, S. typhi, Shigella and Mycobacterium tuberculosis.

It is ineffective against fungi and viruses. Minimum inhibitory concentration ranges from 0, 5-10 micrograms per mL.

Indications

Betamycin-N is indicated in the treatment of a variety of eye infections caused by sensitive organisms.

Eye conditions. Non-infected inflammatory conditions such as non-specific keratitis, conjunctival allergies and acute or chronic uveitis.

Contra-indications

The use of Betamycin-N is contra-indicated in sensitive persons.

Precautions/Warnings

Do not administer to 'red eyes' until a definitive diagnosis is made.

Treatment with corticosteroid preparations should not be prolonged without regular review.

Interactions

Adverse Effects

Eye/ear preparations containing corticosteroids can cause a serious rise in intraocular pressure in a small percentage of the population.

A milder rise in ocular tension may be experienced by a larger proportion of subjects if treatment is continued for no longer than a few weeks.

Neomycin may cause irreversible partial or total deafness. Hypersensitivity reactions usually of the delayed type may occur.

Resistance to Neomycin and other amino-glycosides is acquired.

Dosage & Administration

One or two drops to be instilled into the eye every one or two hours until control is achieved, when the frequency may be reduced.

Storage/Handling Recommendations

Store in a cool, dry and dark place.

SHELF LIFE: 36 Months.

Review Date

2016-05-13 05:36:37