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Acicare

JB Pharmaceuticals Ltd
JB House, 40B Commercial Avenue, Sabo-Yaba, Lagos State, Nigeria
Email: jbpharma@hotmail.com
Tel: 01-793-8369, 234-806-905-5837, 234-803-662-6117
Fax: 01-3425272
Website: http://jbpharma.com

Brand Name

Acicare

Manufacturer

Medibios laboratories Pvt. Ltd. Plot no. J-76, MIDC, Tarapur, Boisar, India.

Therapeutic Class

Antacids

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Granules (NRN: A4-9641): Each sachet (5 gm) contains: Sodium bicarbonate BP 2.8 gm; Tartaric acids BP 1.33 gm; Citric acid BP 0.82 gm; 
Excipeints. Flavouring

Pack Size: 10's

Acicare

Granules (NRN: A4-9644): Each sachet (5 gm) contains: Sodium bicarbonate BP 2.8 gm; Tartaric acids BP 1.33 gm; Citric acid BP 0.82 gm; 
Excipeints. Flavouring

Pack Size: 10's

 Acicare pineapple

Pharmacology

Indications

Acicare reduce the acid content of the stomach thereby reliving indigestion.

In higher dosage, Acicare exerts a mild laxative action.

Acicare makes urine alkaline, thus being of value in the treatment of urinary infections and hence relives associated discomfort.

Contra-indications

Acicare is contraindicated in patients with severe renal impairment and associated oliguria, azotaemia or anuria; untreated Addison's disease; acute dehydration; heat cramps; and severe myocardial damage.

In addition, sodium salts are contraindicated in patients on a sodium-restricted diet.

Acicare should not be administered with urinary tract antiseptics that require acid urine, such as methenamine mandelate and methenamine hippurate.

Precautions/Warnings

Concurrent administration of aluminium antacids and citrate salts is not recommended, especially in patients with renal impairment. Citrate salts taken orally can enhance the absorption of aluminium from the gastrointestinal tract. This may lead to increased serum concentrations of aluminium and encephalopathy, especially in the elderly. lt is recommended that if concurrent use cannot be avoided, the patients should be monitored for possible acute aluminium toxicity (e.g., encephalopathy, seizures, coma) and the dosage adjusted accordingly.

Urinary alkalinizers may increase the excretion and decrease the serum levels of chlorpropamide, lithium, methotrexate, methenamine, salicylates and tetracyclines. This may lead to a decrease in the pharmacological effects of these drugs upon concomitant administration.

Urinary alkalinizers have also been reported to decrease the excretion and increase the serum levels of drugs like mecamylamine, flecainide, quinidine and sympathomimetics, possibly increasing their pharmacological effects.

Acicare should be used with caution in patients with oedematous, sodiumretaining states; congestive heart failure; hypertension; and-pulmonary or peripheral oedema or toxaemia of pregnancy. Serum electrolytes, particularly serum bicarbonate levels, should be monitored in patients with renal disease.

Caution is advised in patients with low urinary output or reduced glomerular filtration rates. Precaution is also advised while using blood products containing citrate in patients with acute liver failure.

Interactions

Adverse Effects

Excessive administration of bicarbonate or bicarbonate-forming compounds may lead to the following:

Hypocalcemia:

Acute hepatic failure is accompanied by impairment of citrate utilization and clearance, and can result in hypocalcemia.

Hypokalemia and metabolic alkalosis:

This occurs particularly in patients with impaired renal function, especially in the presence of hypocalcemia or when excessive doses are given. Symptoms include mood changes, tiredness, shortness of breath, muscle weakness and irregular heartbeat.

Excessive doses of sodium salts may also lead to sodium overload and hyperosmolarity.

Large doses of oral citrate salts may result in gastrointestinal events such as diarrhoea, nausea and vomiting, and a laxative effect. Diluting with large amounts of water and administration after meals can minimize these effects.

Dosage & Administration

The contents of one sachet to be added to half a glass of water and taken, while effervescing, after meals.

Overdosage:

Overdosage with sodium salts may cause serious electrolyte disturbances.

Treatment includes usual supportive measures such as providing an adequate airway and ventilation, and maintaining vascular volume and tissue perfusion. Magnesium sulphate may be given as a cathartic.

Storage/Handling Recommendations

Store in a dry place below 25°C.

Keep all medicines away from the reach of children.

Review Date

2016-06-22 11:50:54