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Leorub

GBGL Pharma Ltd.
16, Oguntona Crescent Phase 1, Gbagada, Lagos, Nigeria
Email: uday@gbglpharma.com
Tel: 0810-540-6002; 0814-503-9010
Website: http://gbpharma.co.uk

Brand Name

Leorub

Manufacturer

Manufactured by:

Tuten Pharmaceuticals, Naroda, Ahmedabad. India.

Manufactured for:

GB PHARMA LIMITED, 65 Chatsworth Road, London NW2 4BG, United Kingdom
Tel.: +44 (0) 20 88301057, Fax: +44 (0) 20 8830 4807, E-mail: info@gbpharma.co.uk

Therapeutic Class

Topical antirheumatics and analgesics

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Gel (NRN:    ): Linseed oil B.P. 3% w/w; Diclofenac Diethylamine B.P. 1.16% w/w (equivalent to Diclofenac Sodium B.P. 1% w/w), Menthol B.P. 5% w/w; Methyl Salicylate B.P. 10% w/w; Benzyl Alcohol (as preservative) B.P. 1% w/w. Gel Base: Carbomer 934 USP Propylene Glycol BP, Disodium Edetate BP, Triethanolamine BP, Polysorbate 80 BP, Citric Acid Monohydrate BP, Butylated Hydroxytoluene BP.

Pack Size: Tube of 30 gm. Box of 12 x 30 gm.

Leo Rub

Pharmacology

Pharmacological Properties: 

Pharmacodynamic Properties:

LeoRub is a non-steroidal anti-inflammatoire (NSAID) and analgesic preparation designed for external application in LeoRub Diclofenac is of the group of nonsteroidal, anti-inflammatory drugs. It inhibits cyclooxygenese, suppresses biosynthesis of prostaglandins endogenous substances, which play a significant role in the genesis of the inflammation, pain and fever.

Diclofenac reduces pain eliminates inflammation. Menthol acts on cold receptiors. It constricts capillaries and dectteases their permeanility, gives sensation of coolness.

Menthol provides local revulsive and moderate analgesic actions. Methyl salicylate is a dertvative of salicyfic acid, which has local irritant action. Methyl selichlate causes formation a great number of biologically active substances and their output into blood because of Irritation of skin receptors. There is a release of P substance from neurons.

Decrease of P substance in nerve endings cause decrease of pain sensation. In addition, Methyl salicylate as one of the group of nonsteroidal anti-inflammatory drugs inhibits synthesis of prostaglandins because of cyclooxygenase inhibition that decreases swelling and infiltration of inflamed tissues. Linseed oil, major component of which is alfalinoteic acid (ether of unsaturated fatty acid) has anti-inflammatory effect, antioxidant properties, Improves blood circulation at the place of application.

Pharmacokinetic Properties:

When LeoRub is applied locally the active substance is absorbed through the skin.

In healthy patients approximately 6 of the dose applied is absorbed as determined by urinary excretion of diclofenac and its hydroxylated metabolites. Diclofenac penetrates Inflamed areas following local application of LeoRub.

After topical administration of LeoRub to hand and knee joints diclofenac can be measured in j plasma, synovial tissue and synovial fluid. For quick relief from Low Back Pain, Muscular Pain and Joint Pain

Indications

LeoRub is indicated in the treatment of back pain, knee pain, sprain and strains, ankle sprain, Wrist sprain, soft tissue disorders, osteoarthritis knee, spondylosis, cervical spondylosis, arthritis, shoulder lesions, frozen shoulder, prolapsed intervertebral disc, thumb, knee, shoulder stiffness, rheumatoid arthritis and tennis elbow.

Contra-indications

LeoRub is contraindicated in individuals with a known history of hypersensitivity to diclofenac and other components of this drug.

LeoRub is contraindicated in patients with or without chronic asthma in whom attacks of asthma, utricaria or acute rhinitis are precipitated by aspirin of other non-steroidal anti-inflammatory agents (NSAIDs).

Precautions/Warnings

LeoRub should be applied only to intact, non-diseased skin and not to skin wounds or open injuries.

It is necessary to wash hands after usage of LeoRub to avoid the accidental entry of drug in eyes and mucous tunics.

Do not apply a double dose.

LeoRub is for EXTERNAL USE ONLY.

Interactions

Avoid using other topical medications containing nonsteroidal anti-Inflammatory drugs, on the affected area.

Adverse Effects

Generally, LeoRub Gel is well tolerated, commonly found adverse effects, with LeoRub are skin rash, oedema and appearance of wheals, papules, scules, reddening. skin itch or prickling may occur in the site of application.

The more uncommon adverse effects with LeoRub are oedema of face (angioedema), apnoea and photosensitivity.

Dosage & Administration

Gently message LeoRub into the affected area until penetration of the gel iscomplete.

Apply 2-3 times daily.

No to be used on children.

Discontinue use if excessive irritation occurs.
Or as directed by Physician.

Overdose:

The low systemic absorption of topical diclofenac renders overdoses extremely unlikely, in the event of accidental ingestion, resulting in Significant Systemic Side-effects, general therapeutic measures normally adopted to treat poisoning with non-steroidal anti-inflammatory drugs should be used or immediately contact with the Physician.

Pregnancy and lactation:

Safety of LeoRub in human pregnancy and lactation has not been established LeoRub is not recommended for use during pregnancy and lactation.

Storage/Handling Recommendations

Store at a temperature not exceeding 30°C.

Protect from light.

Keep all medicines out of the reach of children.

Review Date

2017-05-17 07:25:35