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Doppelherz Aktiv Eye Vital

Agary Pharmaceutical Limited
Plot C39A, Amuwo Odofin Commercial Scheme, Along Alakoso Avenue, Amuwo Odofin, Lagos.
Email: agarypharm@gmail.com
Tel: 0809-275-6424, 0809-275-6425, 0808-745-4848.
Website: http://agarypharm.com/

Brand Name

Doppelherz Aktiv Eye Vital

Manufacturer

Queisser PHARMA GmbH & Co.
KG schleswiger Str. 74 24941 Flensburg Germany

Therapeutic Class

Vitamin/Mineral supplements

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Capsule (NRN: A4-5301): Ingredients: Ascorbic acid (Vitamin C), Glazing agent: Gelatin, Emulsifier: Soybean oil, DL-alpha-Tocopherol (Vitamin E), Humectant: Glycerol, Lutein ester, Zinc gluconate, Humectant: Sorbitol, Anti-caking agent: Wax, Emulsifier: Soya Lecithin, Colour: Iron oxides, Retinyl palmitate (Vitamin A) (dissolved in peanut oil). Energetic Value: 1 capsule corresponds to 3 kcal/ 11 KJ

Nutritional information PER SERVING
Lutein 6 mg
Zeaxanthin 300 µg
Vitamin A 800 µg
Vitamin C 250 mg
Vitamin E 36 mg
Zinc 2.5 mg

Pack size: 2×15’s (in blisters)

DH eye vital

Pharmacology

Age related macular degeneration (AMD) is a disease that impairs function of the macula, first leading to altered vision in the center of the vision field and progressing towards complete blindness. AMD is the major cause of disease-related blindness.

Reactive oxygen species play a large role in its development of AMD. High-energy visible light (blue light with a wavelength of about 450 nm) can generate reactive oxygen species (ROS). ROS produce radicals that alter cellular structures and components such as lipids, proteins, nucleic acids.

Long-term use of Eye vital decreases risk of developing advanced stages of AMD through antioxidant properties and increase of the macular pigment density. Visual acuity improves within a few months.

Combined anti radical action of vitamin C, E, lutein, zeaxanthin and zinc at three levels:

  1. Neutralize free radicals and oxidizing agents
  2. Slow-down progression of lipid peroxidation
  3. Prevent formation of new radicals

Additional advantage: One capsule is sufficient to protect, preserve and improve vision.

  • Zinc (Zn) optimizes the activity of the Zn-dependent superoxide dismutase responsible for the neutralization of ROS. Zn also has an intrinsic antioxidant activity and specifically protects metal-containing proteins from oxidation.
  • Vitamin C and vitamin E are two powerful antioxidants that participate in a cellular redox system that is physiologically essential. Vitamin C concentration in the vitreous humor is about 20 times higher than in serum. Vitamin C blocks in the aqueous environment of the cytoplasm prevent the propagation of chain reactions initiated by ROS which produce harmful molecule radicals.  Vitamin E has a similar function in the hydrophobic environment of the phospholipid membranes of cells.
  • Vitamin A is present in Eye Vital capsules in form of retinol. Vitamin A is required for growth, bone development, vision, reproduction, maintenance of mucosal and epithelial surfaces. Vitamin A for an optimal vision, especially at night. Vitamin A has an antixerophthalmic activity: in the retina it combines with the rod pigment opsin to from rhodopsin necessary for visual dark adaptation. Absence of a constant dietary supply of vitamin A leads to night blindness.
  • Lutein and zeaxanthin: Lutein and zeaxanthin are carotenoids that specifically accumulate in the macula.  They are strong antioxidants, capable of quenching singlet oxygen and free radicals, thereby limiting membrane phospholipid peroxidation. Their absorption spectrum peaks at 460 nm constitutes a blue light filter that limits blue light-induced photo-oxidative damage to retinal cells. Zeaxanthin is the strongest antioxidant carotenoid found in your retina.

Pharmacokinetics:

  • Vitamin A is a lipid-soluble vitamin that is readily absorbed from the gastrointestinal tract. Plasma concentrations peak within 3 to 5 hours. Retinol or its esterified form retinyl palmitate are stored in small amounts in the liver.
  • Vitamin E absorption from the gastrointestinal tract depends on biliary and pancreatic secretions, micelle formation, uptake into erythrocytes, and chylomicron secretion. Absorption rate is rather low, with 20-60% absorbed from dietary sources.
  • After intestinal absorption, lutein and zeaxanthin reach a peak in the chylomicron fraction two hours post-ingestion. Plasma levels peak at about 16 hours. Lutein and zeaxanthin are distributed to various tissues through transport by HDL and LDL vesicles. 
  •  Absorption of vitamin C in the intestine is dependent on its initial concentration, with efficacy diminishing with the amount of vitamin C. Not absorbed vitamin C is degraded by the intestinal flora. Normal plasma concentrations are in the range 0.8 to 1.0 mg/dl. Half-life in the blood is about 2.9 hours, determined by renal filtration / reabsorption and secretion rates.
  •  Zinc is present as gluconate conjugate. It is absorbed to about 30% in the intestine, where it binds to the protein metallothionein which serves as zinc store. Endogenous zinc can be reabsorbed in the ileum and colon, creating an enteropancreatic circulation of zinc.

Indications

  • Prevention of Age Related Macular Degeneration
  • To maintain night vision
  • To preserve and improve visual acuity

Contra-indications

Eye Vital contains 250 mg vitamin C per capsule. Therefore it should not be taken by people with iron-load disorders (haemochromatosis, thalassemia, sideroblastic anemia).

Precautions/Warnings

  • Adhere to the dosage recommended
  • Food supplements should not be used as a substitute for varied food

Interactions

• Cholestyramine, a class of bile acid sequestrants, Orlistat and other inhibitors of intestinal fat uptake might prevent proper absorption of vitamins A and E and of lutein and zeaxanthin.

• When taken over prolonged time, vitamin A may increase risk of bleeding of people taking blood-thinning medications.

• Vitamin E might interfere with proper absorption and effectiveness of certain antidepressant, antipsychotic and beta blockers.

• Aspirin and non-steroidal anti-inflammatory drugs increase urine excretion of vitamin C.

• Zinc might interfere with uptake of quinolones and tetracyclines antibiotics. Zinc also reduces the effectiveness of non-steroidal anti-inflammatory drugs.

Adverse Effects

None reported.

Dosage & Administration

One capsule daily at meal with enough liquid. Do not chew.

Do not exceed the stated recommended daily dosage. Food supplements should not be used as a substitute for a varied diet.

Storage/Handling Recommendations

Store below 25˚C. Keep away from direct sunlight.
Keep out of the reach of children.

Review Date

2017-09-15 10:12:48