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Doppelherz Aktiv Garlic with Hawthorn

Agary Pharmaceutical Limited
Plot C39A, Amuwo Odofin Commercial Scheme, Along Alakoso Avenue, Amuwo Odofin, Lagos.
Email: agarypharm@gmail.com
Tel: 0809-275-6424, 0809-275-6425, 0808-745-4848.
Website: http://agarypharm.com/

Brand Name

Doppelherz Aktiv Garlic with Hawthorn

Manufacturer

Queisser PHARMA GmbH & Co.
KG schleswiger Str. 74 24941 Flensburg Germany

Therapeutic Class

Vitamin/Mineral supplements

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Capsule (NRN: A7–0817): Ingredients: Brassica oil, Gelatin, Garlic oil macerate extract, Hawthorn berries oil macerate extract, Glycerol, butterfat, Silica, Water, Caramel (E 150). Energetic Value: 1 capsule corresponds to 2 kcal/ 8 KJ

Nutritional information PER SERVING
Garlic Oil Macerate 60 mg
Mistletoe Oil Macerate 24 mg
Hawthorn 54 mg

Pack Size: 3 × 30’s (in blisters)

DH garlic hawthorne

Pharmacology

Doppelherz® aktiv Garlic with Hawthorn contains oil-macerated garlic, mistletoe and hawthorn extracts that are traditionally used to invigorate heart function and blood circulation and to help keep blood pressure in the normal range. Garlic prevents artery calcification, Mistletoe helps to reduce blood pressure and Hawthorn enhances blood circulation thereby ensures better supply of oxygen. In addition, hawthorn has anti-oxidative effects and helps against inflammation.

The specially developed enteric coated capsules release the active ingredients in the intestine. The extra coating protects the inner capsule against the gastric juice, thus the whole capsule passes through the stomach. Due to the delayed release, the capsules are without odour.

Features: Odorless, No upset stomach, Concentrated form and Biochemical transformations during maceration leading to biological activity.

Garlic is of special importance for people of advanced age, in particular for protection against the general calcification of our cardiovascular system. Due to the higher demand in our daily life, young people can also benefit from the positive effects of doppelherz® aktiv. Garlic capsules on the health as well. Hawthorn has anti-oxidative effects and helps against inflammation. Therefore, it plays a role in keeping a healthy heart.

One of the best-known and strongest activity of Doppelherz® Garlic capsules is the prevention of atherosclerosis. The garlic extract acts at different levels in the chain of events leading to atherosclerosis: it decreases LDL cholesterol and triglycerides levels and at the same time slows down free radical formation, which decreases LDL oxidation. The garlic extract also directly inhibits atheroma plaque formation.

On the long term, intake of the garlic extract reduces the risk of cardiovascular events because it:

-lowers blood pressure, partly by acting vaso-relaxation

 

-improves microcirculation

 

-increases fibrinolysis (elimination of neo-formed blood clots)

 

-prevents platelets aggregation (leading to formation of blood clots and potentially to thrombosis)

In vitro experiments show that DADS and DATS, two of the metabolites formed during garlic maceration, support the detoxification function of liver cells and protects nerve cells from oxidative stress. DADS and DATS stimulate expression of the enzyme Glutathione-S-transferase which neutralizes toxins in the cells.

DATS and DADS are used as substrates for the enzymatic production of H2S, a gas which functions as gasotransmitter. H2S acts on vascular smooth muscles to trigger vasodilatation in the peripheral and cerebral circulation. H2S exerts its physiological actions by covalently modifying the sulfhydryl group of cysteines in target proteins in a process termed S-sulfhydration. The vasodilating actions of H2S are associated with sulfhydration of a specific cysteine in ATP-sensitive potassium (KATP) channels of blood vessels, activating the channels and hyperpolarizing the vascular endothelial and smooth muscle cells.

Garlic elicits the following pharmacological effect:

     Decrease Low Density Lipoprotein  and Triglyceride levels

     Vasodilatation

     Increased  antioxidant production

     Inhibition of platelet aggregation

 

Beneficial effects of garlic extracts have to be attributed to allicin degradation products sulfides, vinyldithiins and ajoenes.

Hawthorn contains flavonoids and proanthocyanidins which strengthens the heart and improves blood circulation in the coronary arteries that means a better supply of oxygen and the physical capacity of the heart increases. Hawthorn also has antioxidative and anti-inflammatory effects that contributes to a healthy cardiovascular system.

From the longstanding traditional use, it is known that hawthorn strengthens the heart and improves blood circulation in the coronary arteries. Hawthorn extract can be used as an adjunctive treatment for chronic heart failure. The benefits include:

  • Higher exercise tolerance
  • Increased maximal workload
  • Less shortness of breath and fatigue

Pharmacokinetics: Renal clearance accounts for 92% excretion of allicin metabolites (like vinyldithiins) in 72 h.

Indications

Hypertension, Cardiovascular diseases, prevents atherosclerosis, prevents coronary artery thrombosis, strengthens the hear tand promotes blood circulation

Contra-indications

  • Pregnant and breast-feeding women should not consume garlic in form of capsules.
  • Allergy to garlic, mistletoe and hawthorn
  • Stop intake at least one week before surgery

Precautions/Warnings

Interactions

Do not take garlic in combination with anticoagulants and antiplatelets drugs.

Adverse Effects

Dosage & Administration

Adults: One-Two capsules 3 times daily at meal with enough liquid. Do not chew.

Do not exceed the stated recommended daily dosage. Food supplements should not be used as a substitute for a varied diet.

Storage/Handling Recommendations

Store below 25˚C. Keep away from direct sunlight.

Keep out of the reach of children.

Review Date

2017-09-15 10:15:48