Afrab-Chem Ltd
No. 22, Abimbola Street, Isolo Industrial Estate, Isolo, P.O. Box 1647, Lagos, Nigeria.
Tel: 234-1-2700057
Fax: 234-1-4520328

Brand Name



Afrab Chem Ltd, 22 Abimbola Street, Isolo Ind. Estate, Isolo, Lagos.

Therapeutic Class

Antimalarial drugs

Dosage Form, Composition & NAFDAC Registration Number (NRN)

Oral drops (NRN:04-7341): Each droperful (1 mL) contains: Chloroquine phosphate BP 60 mg equiv. to 37.5 mg Chloroquine base.

Pack size: Amber glass bottle of 10 mL.



Antimalarial action may occur through inhibition of protein synthesis and alteration of DNA in susceptible parasites.


Chloroquine drop is indicated for the prevention and treatment of malaria.


Care is necessary in administering chloroquine to patients with impaired liver or renal function or with porphyria and psoriasis. Reactions are more common in alcoholics.

The concurrent administration of chloroquine with drugs capable of inducing blood disorders such as gold salts should be undertaken with caution, if at all.

Patients receiving long courses of treatment with chloroquine should undergo regular examination for ocular disturbances.


Use cautiously in:
• Severe GI, neurologic, or blood disorders; hepatic impairment; G6PD deficiency; neurologic disease; eczema; alcoholism
• Pregnant patients
• Children


Drug-drug: Aluminum and magnesium salts, kaolin: decreased GI absorption of chloroquine

Ampicillin: reduced ampicillin bioavailability

Cimetidine: decreased hepatic metabolism of chloroquine

Cyclosporine: sudden increase in cyclosporine blood level

Adverse Effects

Chloroquine is generally well tolerated when given in anti-malarial doses and adverse effects are rare. Side effects occurring with anti-malarial doses are usually reversible on withdrawal of the drug.

Overdosage is especially dangerous in children and after intravenous use. Headache, drowsiness, respiratory and cardiovascular depression, shock, visual disturbances and severe gastrointestinal irritation may be followed by convulsion, respiratory and cardiac arrest and death.

Prolonged administration of higher doses may lead to cornea and retinal changes. Changes may occur long after the drug has been withdrawn. Pigmented deposits and opacities in the cornea are often reversible if the drug is withdrawn early enough but retinal damage, with macular lesions, defects of colour vision, pigmentation,  optic nerve damage and blindness have been reported and are usually irreversible.

Other uncommon side effects from prolonged use include loss of hair, bleaching of hair pigment, photosensitivity, tinnitus, reduced hearing, nerve deafness, neuromyopathy and myopathy.

Dosage & Administration

 Age  Dose   
 Day 1 Day 2  Day 3 
 Children under 1 year   75 mg - 1 mL dropperful   75 mg - 1 mL dropperful   37.5 mg - ½ mL dropperful

If symptoms persist two days after the commencement of treatment, consult your Physician.

Storage/Handling Recommendations

Keep in a cool dry place and away from children.

Review Date

2017-09-20 03:12:45